WIP 134 - Maternal Hypertensive Disorders in Pregnancy and the Development of Congenital Heart Disease (CHD) in the Offspring - A Retrospective Study in the South Bronx Population
Resident BronxCare Health System Bronx, New York, United States
Background: Congenital Heart Disease (CHD) represents the most common birth defect, affecting approximately 1% of all live births. They are the most common cause of infant deaths associated with birth defects. Retrospective studies and meta-analysis from United States, Europe and Canada have shown an association of Maternal Hypertensive Disorders with CHD, with some studies showing up to a three-fold increase in the risk of CHD in newborns. Maternal hypertensive disorders occur in 2-10% of all pregnancies and include chronic hypertension, gestational hypertension, pre-eclampsia and eclampsia. There is paucity of data showing the association of specific CHD with maternal hypertensive disorders. Prevalence of maternal HDP overall in United States is 14.6%, with increased prevalence of 18% in the black women when compared to other ethnic groups. Objective: To evaluate the association of maternal hypertensive disorders with congenital heart disease in the offspring in the South Bronx population from years 2016-2021. Design/Methods: Retrospective chart review, identifying mothers with and without hypertensive disorders in pregnancy (HDP) using International Classification of Diseases (ICD) codes for chronic hypertension (CHTN), gestational hypertension (GHTN), and preeclampsia. We included offsprings with and without CHD as determined by ICD codes. CHD will be identified by fetal anatomy scan and/or physical exam findings, confirmed with echocardiogram. Inclusion criteria were singleton pregnancies carried to 37 completed weeks of gestation. Cases were further subclassified according to type of congenital heart lesions. Preterm infants < 37 weeks gestation, spontaneous abortions, chromosomal abnormalities, and those lost to follow-up, were excluded from the study.
