Resident Weill Cornell Medicine Brooklyn, New York, United States
Background: Total parenteral nutrition (TPN) is used to manage the nutritional needs of newborns in the neonatal intensive care unit (NICU), particularly when enteral feeding cannot be established in the first few days of life. Early use of parenteral nutrition may improve growth outcomes in critically ill neonates. Calories are provided through macronutrients, which include carbohydrates, proteins, and lipids. Dosing practices may vary between patients due to changes in clinical status and corresponding lab work. Objective: The objective of this study is to evaluate the appropriateness of macronutrients dosing in parenteral nutrition provided at our institution and its association with postnatal growth. Design/Methods: A single-center, retrospective chart review will be conducted on patients admitted to the NICU and received TPN from January 2022 to August 2023. Patients were excluded from the analysis if they were on prolonged TPN (defined as longer than 4 weeks), had TPN discontinued and restarted, or had genetic or cardiac abnormalities. Data will be collected via electronic medical records. The primary endpoint is the time to regain birth weight. Secondary endpoints include dosing compliance of macronutrients compared with guidelines, time to full enteral feeds, weight gained at time of discharge, length gained at time of discharge, head circumference gained at time of discharge, length of hospital stay, and safety. Descriptive statistics will be used for describing baseline characteristics. This study has been approved by the Institutional Review Board at NewYork-Presbyterian Brooklyn Methodist Hospital.
