WIP 53 - Role of Induction of Labor as a Risk Factor for Transient Tachypnea of the Newborn and its Effect on the Outcome of Transient Tachypnea of the Newborn

Poster Number: WIP 53
Publication Number: WIP 53.2651

Background: Transient Tachypnea of the Newborn (TTN) is responsible for approximately 40% of cases of respiratory distress in term and late term neonates. The pathophysiology of TTN is based on delayed resorption of alveolar fluid and studies show that the lung liquid clearance starts well before term birth. We propose that induction of labor as opposed to spontaneous labor may possibly contribute to delayed lung fluid clearance and increase the risk of TTN in neonates. Knowledge of the impact of induction of labor on the incidence and outcomes of TTN, plays an important role in prevention, diagnosis and management of this common differential of neonatal respiratory distress.

Objective: To evaluate the role of induction of labor in mothers as a risk factor for TTN as well as its effect on the outcomes of TTN.

Design/Methods: This retrospective chart review is approved by SUNY Downstate Institutional Review Board (IRB) under exempt review category. We are collecting data of mothers who delivered babies at > 37 weeks of gestation, at the Kings County Hospital between January 2019 and January 2023. Those mothers who delivered by spontaneous or induced labor are included in the study, while those who required vacuum/forceps extraction or C-section are excluded from the study. TTN will be diagnosed based on the clinical and radiological picture. The incidence of TTN will be calculated and compared between the infants born via spontaneous labor and those born via induced labor. Chi square test and univariate logistic regression will be done for comparison, followed by multivariate logistic regression to account for the various maternal and infant confounding factors. To show a significant difference between the 2 groups, the sample size is calculated to be 2200 babies, based on the 5% incidence of TTN in term babies at our center. We plan to complete the data collection by the end of February and analyze the data by mid-March. Datasets and results will be complete by April 1, 2024, for presentation at the PAS 2024 Meeting.