Resident physician PGY-2 University of California, Los Angeles David Geffen School of Medicine Los Angeles, California, United States
Background: Ischemic placental disease (IPD) clinically presents as preeclampsia, intrauterine growth restriction, birth of small for gestational age (SGA) infant, or placental abruption. The early gestation MRI detected placental hypoperfusion creates a deprived intrauterine environment for the fetus, causing restriction in proper fetal growth resulting in SGA infants. The effect of IPD on further neonatal growth trajectory and neonatal outcomes remains to be examined. Objective: To investigate the effect in the delivery and growth of neonates from women diagnosed prenatally with ischemic placental disease (IPD) compared to those without IPD. Design/Methods: In the previous IRB-approved prospective study, 199 women were recruited for temporal investigation. They had maternal magnetic resonance imaging studies of their placentas at 14-16 weeks gestational age (GA) and 19-24 weeks GA. The 199 women were distributed between the IPD group and the non-IPD or the control group. We conducted a retrospective chart review of neonates born to these women in the IPD group (N = 30) and those to women in the non-IPD group (N = 169). Neonates who did not get their primary care at our institution were excluded. At birth, data on their APGARs, birth weight, birth length, and birth head circumference were gathered. The percentiles of their measurements were determined using the Fenton growth chart. Delivery method and any complications were examined (sepsis rule out, resuscitation, prematurity, and SGA). Their weights, lengths, and head circumferences were collected from their 2-week, 2-month, and 4-month well-child check visits. The percentiles of these measurements were determined using the WHO growth chart. Once all chart review is completed, we will be performing logistic regression analysis to control for potential cofounders of the IPD-outcome association. The chart review of data already collected will be completed by December 2023. The analysis will be completed by the end of January 2024.
