Academic and Research Skills
Children with Chronic Conditions
Developmental Biology
General Pediatrics
Hospital Medicine
Neonatology
Pharmacology and Therapeutics
Pulmonology
Trainee
Richard Martin, MD (he/him/his)
Professor
Pediatrics/Reproductive Biology/Physiology & Biophysics
Case Western Reserve University School of Medicine
Cleveland, Ohio, United States
Session
Description: Our session will bring the use of caffeine in the neonate to the forefront with a very current discussion of the following: Dr. Martin, a world expert in apnea of prematurity, will discuss the known mechanisms of action of caffeine including adenosine-receptor subtypes and recent anti-inflammatory and anti-oxidant data. This presentation will delineate the mechanisms of action needed to understand using caffeine in the NICU. Dr. Eichenwald, who contributed much to our early clinical understanding of apnea of prematurity, will summarize the evidence basis for the timing, dose and duration of caffeine therapy in the NICU. Dr. McPherson is an expert in caffeine pharmacology. He will describe the robust clinical trials used to inform the standard dosing and timing of caffeine citrate in neonatal intensive care. Dr. Van Kaam from the Netherlands will bring a non-US perspective on caffeine usage. Although the use of caffeine for treating apnea of prematurity is undisputed, its effect on the number of hypoxemic events is not always sufficient. This presentation summarizes adjuvant therapies to caffeine and addresses the rationale and evidence for caffeine use for other indications. Finally. Dr. Cheong from Melbourne, Australia, will discuss longer-term outcomes of preterm infants treated with caffeine. This presentation summarizes the evidence around the long-term neurobehavioral and respiratory function at school age for preterm infants exposed to caffeine to treat apnea of prematurity. We have left time for questions and discussion at the end of the session for all speakers and moderators.
Speaker: Richard Martin, MD (he/him/his) – Case Western Reserve University School of Medicine
Speaker: Eric Eichenwald, MD (he/him/his) – Perelman School of Medicine at the University of Pennsylvania
Speaker: Christopher McPherson, PharmD, BCPPS (he/him/his) – Washington University in St. Louis School of Medicine
Speaker: Anton H. van Kaam, MD, PhD – Emma Children's Hospital Amsterdam UMC
Speaker: Jeanie Cheong, MBBS MD – Murdoch Children's Research Institute