Skip to main content
PAS 2024 Meeting Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Pre-Conference Ticketed Event
Pre-Conference Ticketed Event
APA Award Winner
APA Award Winner
APS Award Winner
APS Award Winner
ASPN Award Winner
ASPN Award Winner
SPR Award Winner
SPR Award Winner
On Demand Presentation
On Demand Presentation
Poster Icons
SPR Award Winner
SPR Award Winner
Back
Evaluation ViewAttendees 104
Hot Topic Symposia

Cardiology

Developmental Biology

Neonatology

Pulmonology
Session Type: Hot Topic Symposia

Nitric Oxide Resistant Acute Pulmonary Hypertension in Neonates

Monday, May 6, 2024
8:00 AM – 9:30 AM ET
Location: Metro Toronto Convention Centre: 106
CE: Live CME: 1.5

Selected By: PAS Program Committee Leadership Team
Co-sponsored By: Neonatal
Disclosure(s):
Amish Jain, MD PhD: Mallinckrodt pharmaceuticals (Terminated, June 30, 2023) (Products/Services: Research Support including clinical trials & the principal or named investigator)
Steve Abman, MD: Chiesi (Ongoing) (Products/Services: Consultant); Oak Hills Bio (Ongoing) (Products/Services: Advisory Committee)

Session

Description: Among neonates, severe hypoxemic respiratory failure (HRF) unresponsive to treatment with inhaled nitric oxide (iNO) is associated with high mortality and morbidity and are some of the most challenging cases in clinical practice. Poor responsiveness to iNO can be observed in the presence of lung airway and parenchymal disease with insufficient distal lung recruitment or poor distribution of gas throughout the lung; pulmonary hypertension that is primarily due to extrapulmonary shunt; or in the setting of abnormal cardiac performance and impaired systemic hemodynamics. This symposia will review the pathophysiology and state-of-the-art cardiorespiratory management of iNO unresponsive HRF, including practical application with clinical cases.

Moderators: Amish Jain and Steve Abman

Audience: Neonatologists, cardiologists, intensivists, respiratory therapists

1) Introduction to iNO Resistant acute pulmonary hypertension
Steve Abman

2) Pathophysiology of iNO Resistance
Satyan Lakshminrusimha

3) Respiratory Management of iNO Resistant Pulmonary Hypertension
Michelle Baczynski

4) Echocardiographic Features of Pulmonary Hypertension Not Responding To iNO
Bonny Jasani

5) Pulmonary Vasodilator Therapy Beyond iNO
Dany Weisz

6) Cases and Discussion
Faith Zhu

Learning Objectives:

  • Understand the pathophysiology underlying non-responsiveness to inhaled nitric oxide among neonates with hypoxemic respiratory failure.
  • Synthesize clinical, laboratory and echocardiography evaluations of neonates with iNO resistant hypoxemic respiratory failure to develop a pathophysiology-based cardiorespiratory management plan.
  • Identify the indications for alternative pulmonary vasodilator therapy and potential therapeutic agents.

Presentations:

  • 8:00 AM – 8:05 AM ET
    Introduction to iNO Resistant Pulmonary Hypertension

    Speaker: Steve Abman, MD (he/him/his) – University of Colorado School of Medicine

  • 8:05 AM – 8:20 AM ET
    Pathophysiology of iNO Resistance

    Speaker: Satyan Lakshminrusimha, MD FAAP (he/him/his) – UC Davis Children's Hospital

  • 8:20 AM – 8:35 AM ET
    Respiratory Management of iNO Resistant Pulmonary Hypertension

    Speaker: Michelle Baczynski, Bsc – Mount Sinai Hospital

  • 8:35 AM – 8:55 AM ET
    Echocardiographic Features of Pulmonary Hypertension Not Responding to iNO

    Speaker: Bonny Jasani, MBBS, MD, DM (he/him/his) – The Hospital for Sick Children

  • 8:55 AM – 9:10 AM ET
    Pulmonary Vasodilator Therapy Beyond iNO

    Speaker: Dany Weisz, MD MSc – University of Toronto

  • 9:10 AM – 9:30 AM ET
    Q & A: Discussion of Two Cases

    Speaker: Faith Zhu, MBChB (she/her/hers) – University of Toronto Temerty Faculty of Medicine