CureGRIN Foundation

GRI Disorders are rare monogenic diseases caused by variants in the GRIN, GRIA, GRIK and GRID genes. While many people with GRI Disorder never have seizures, GRI Disorders are considered Developmental and Epileptic Encephalopathies (DEEs).

Common symptoms include intellectual and physical disabilities, epilepsy, cortical visual impairment, movement disorders and dysautonomia, as well as speech, sleep, feeding, and GI challenges.

GRI Disorders are usually diagnosed through Whole Exome Sequencing.

There are 18 genes that encode Ion Glutamate Receptors (iGluRs), at least 15 of which have are believed to include pathogenic variants in the human population (GRIA1 GRIA2 GRIA3 GRIA4 GRID1 GRID2 GRIK2 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D and GRIN3A).

CureGRIN Foundation is a globally-focused charity based in the US. We're dedicated to improving the lives of people around the world with GRI Disorder, and their families, through research, education and connectivity. We work closely with scientists and the medical community to drive patient-centered research that will lead to treatments and cures.