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Evaluation ViewAttendees 61
Panel Discussion

Basic Science

Clinical Research

Developmental Biology

Neonatology

Neurology
Session Type: Panel Discussion

Neuroplacentology: Placental Connections to Brain Development and Neurologic Outcomes

Monday, May 6, 2024
8:00 AM – 9:30 AM ET
Location: Metro Toronto Convention Centre: 104 CD
CE: Live CME: 1.5

Selected By: NBS
Co-sponsored By: CNS, Neonatal
Disclosure(s):
Anna Penn, MD PhD: I do not have any relevant financial / non-financial relationships with any proprietary interests.
Rachel L. Leon, MD, PhD: I do not have any relevant financial / non-financial relationships with any proprietary interests.
Imran N. Mir, MD: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Session

Description: Neuroplacentology is a growing field that explores the myriad ways that placental function and dysfunction affect the developing fetal brain and both short and long term neurologic outcomes. This session will feature research on de-novo hormone synthesis of the placenta and discuss how these hormones target the development of specific fetal brain regions. Speakers will cover novel imaging methods to measure placental function and address how placental hemodynamics affect vulnerable populations both pre- and postnatally, such as those with congenital heart disease. This session will also include discussions on the role of acute and chronic placental inflammation in neurologic diseases of high-risk infants and long-term consequences. New results on placental alterations from prenatal stress and the impacts on developing brain will also be presented. The overall goal of this session is to expand appreciation of the critical role of the placenta in fetal brain development and its lasting influence on neurologic outcomes.

Learning Objectives:

  • Discuss the many roles of the placenta in fetal brain development.
  • Understand the current models and tools used to assess placental function and their limitations.
  • Describe how placental abnormalities can manifest as changes in typical neurologic development.

Presentations:

  • 8:00 AM – 8:20 AM ET
    Placental Hormones in Brain Development and Injury

    Speaker: Anna Penn, MD PhD (she/her/hers) – Columbia University Vagelos College of Physicians and Surgeons

  • 8:20 AM – 8:35 AM ET
    Chronic Placental Inflammation and Postnatal Cerebrovascular Response in Neonates with Congenital Heart Disease

    Speaker: Rachel L. Leon, MD, PhD (she/her/hers) – University of Texas Southwestern Medical School

  • 8:35 AM – 8:50 AM ET
    Impact of Placental Inflammation on Neurodevelopmental Outcomes in Term and Preterm Infants

    Speaker: Imran N. Mir, MD (he/him/his) – University of Texas Southwestern Medical School

  • 8:50 AM – 9:05 AM ET
    Influence of Placental Dysfunction on Early Brain Development in CHD: Novel Insights using MRI

    Speaker: Vidya Rajagopalan, PhD (she/her/hers) – Children’s Hospital of Los Angeles

  • 9:05 AM – 9:20 AM ET
    CRISPR Modification of Placental Igf-1 and Neurobehavioral Outcomes

    Speaker: Hanna Stevens, MD PhD (she/her/hers) – University of Iowa Carver College of Medicine