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Evaluation ViewAttendees 33
Hot Topic Symposia

Basic Science

Children with Chronic Conditions

Clinical Research

Nephrology
Session Type: Hot Topic Symposia

Nephrogenetics in nephrotic syndrome

Saturday, May 4, 2024
2:00 PM – 3:30 PM ET
Location: Metro Toronto Convention Centre: 803 A
CE: Live CME: 1.5

Selected By: ASPR
Disclosure(s):
Kandai Nozu, MD, PhD: Chugai Pharmaceutical Co. Ltd (Ongoing) (Products/Services: Speaker Honorarium including speakers bureau, symposia, and expert witness); Kyowa Kirin Co. Ltd (Ongoing) (Products/Services: Advisory Committee); Sumitomo Pharma Co., Ltd (Ongoing) (Products/Services: Speaker Honorarium including speakers bureau, symposia, and expert witness); Toa Eiyo LTD (Ongoing) (Products/Services: Advisory Committee)

Session

Description: Genetic and genomic studies have the potential to provide important new insights into the mechanisms of renal disease and to identify new therapeutic targets.
Approximately 90% of the patients with childhood-onset nephrotic syndrome are idiopathic of unknown etiology. Advances in genetics have identified single-gene abnormalities in some cases of congenital nephrotic syndrome, infantile nephrotic syndrome, and steroid-resistant nephrotic syndrome. And disease susceptibility genes have also been identified in steroid-sensitive nephrotic syndrome, considered a multi-factorial genetic disease. We are entering a new phase in developing personalized medicine now.
In this symposium, we would like to deepen our understanding of the latest knowledge, the discovery process, and the possibility of applying it to new treatments for nephrotic syndrome in the future.

Learning Objectives:

  • Upon completion, participants will be able to understand the single-gene mutations in patients with congenital nephrotic syndrome, infantile nephrotic syndrome, and steroid-resistant nephrotic syndrome.
  • Upon completion, participants will be able to understand the disease susceptibility genes identified in steroid-sensitive nephrotic syndrome, a multifactorial genetic disease.
  • Upon completion, participants will be able to understand the impact of nephrin autoantibodies on future treatment of nephrotic syndrome.

Presentations:

  • 2:00 PM – 2:20 PM ET
    Pediatric Nephrotic Syndrome - A Comprehensive Overview

    Speaker: Jiwon M. Lee, MDPhD (she/her/hers) – Korea Disease Control and Prevention Agency (Korea CDC)

  • 2:20 PM – 2:40 PM ET
    Genetic Origins of Nephrotic Syndrome: Monogenic Perspectives

    Speaker: Yutaka Harita, MD, PhD – The University of Tokyo

  • 2:40 PM – 3:00 PM ET
    Unraveling the Genetic Mechanisms Behind Steroid-Sensitive Nephrotic Syndrome

    Speaker: Michelle T. McNulty, MS (she/her/hers) – Boston Children's Hospital

  • 3:00 PM – 3:20 PM ET
    Impact of Anti-Nephrin Antibody Detection on Treatment Strategies for Nephrotic Syndrome

    Speaker: Tomoko Horinouchi, MD,PhD – Kobe University Graduate School of Medicine