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Evaluation ViewAttendees 35
State of the Art Plenary

Clinical Research

Critical Care

General Pediatrics

Hospital Medicine

Neonatology

Pharmacology and Therapeutics

Trainee
Session Type: State of the Art Plenary

Beyond mg/kg: A Paradigm Shift in Drug Dosing – Pharmacokinetic Model-Informed Precision Dosing (MIPD) to Improve Outcomes

Sunday, May 5, 2024
11:00 AM – 12:30 PM ET
Location: Metro Toronto Convention Centre: 717 B
CE: Live CME: 1.5

Selected By: CHTRC
Disclosure(s):
Tamorah Lewis, MD, PhD: I do not have any relevant financial / non-financial relationships with any proprietary interests.

Session

Description: There is a translation chasm between the rich world of pediatric pharmacokinetic studies and improved patient dosing at the bedside. Model-informed precision dosing (MIPD) is a paradigm-shifting tool that can help prescribers create individualized doses for children, instead of current population-based drug dosing. MIPD can be used in various populations including (1) stages of rapid organ development, (2) organ impairment, (3) drug-drug interactions or (4) in drug with high risk and narrow therapeutic index, among others.

Talk 1: Are you less familiar with the terms “pharmacokinetics”, “modeling and simulation”, and “model-informed precision dosing”, but would like an improved understanding to connect these concepts to your practice? In addition to receiving an introduction to these concepts, you will also learn the basics of pharmacokinetic modeling and pharmacometrics for pediatrics.

Talk 2: The underpinnings for MIPD to support clinical decisions were established in the 1960s. Although these concepts have been utilized with significant impact in advancing MIPD broadly, little progress has been made in advancing clinical therapeutics on an individual patient level. Many of the intellectual and technological barriers no longer impede the progress toward a more data-driven and MIPD paradigm for routine clinical care.

Talk 3: This talk will briefly review the components of MIPD and discuss how these principles are being implemented at the patient’s bedside via the Pharmacokinetic Consultation Service at Cincinnati Children’s Hospital Medical Center.

Talk 4: During this talk, a NIH-funded feasibility study of MIPD in the NICU will be described, including presentation of novel research data.

Learning Objectives:

  • Upon completion, participants will be able to discuss the basics about different types of PK modelling approaches in pediatric populations (popPK and PBPK)
  • Upon completion, participants will be able to learn how PK models can be validated and applied for the purposes of precision dosing (Beyond mg/kg)
  • Upon completion, participants will be able to describe examples of how to build a MIPD program and successes in pediatric dosing improvement

Presentations:

  • 11:00 AM – 11:15 AM ET
    Pharmacokinetic modelling for pediatricians: Unique approaches to describe drug clearance and optimize drug doses in children

    Speaker: Cindy Hoi Ting Yeung, MSc, PhD – The Hospital for Sick Children

  • 11:15 AM – 11:30 AM ET
    The time is now for model informed precision dosing for routine patient care

    Speaker: Vijay Ivaturi, MS PhD – Pumas-AI, Inc.

  • 11:30 AM – 11:45 AM ET
    Optimizing Target Attainment: An Overview of Cincinnati Children's Model-Informed Precision Dosing Service

    Speaker: Zachary L. Taylor, PhD, MS (he/him/his) – Cincinnati Children's Hospital Medical Center

  • 11:45 AM – 12:00 PM ET
    New frontiers of MIPD: Bringing precision dosing to the smallest patients in the Neonatal ICU

    Speaker: Tamorah Lewis, MD, PhD (she/her/hers) – University of Toronto Temerty Faculty of Medicine