Fellow Connecticut Children's Medical Center/UCONN Plainville, Connecticut, United States
Background: NIRS is a non-invasive method of measuring mixed venous tissue oxygenation and is highly sensitive for detecting acute changes in oxygen use and delivery. It is unknown whether use of NIRS predicts changes in renal perfusion caused by nephrotoxic agents that may alter normal renal postnatal transition. Objective: Determine whether renal NIRS values are reduced in neonates exposed to ampicillin and gentamicin. Design/Methods: This was a case-control study. We included infants ≥30 weeks gestation who received antibiotics within 6 hours of birth. Exclusion criteria included transfers in, infants < 30 weeks gestation, with PPHN, undergoing therapeutic hypothermia, and known congenital disorders. A NIRS probe was placed on the flank area for 72 hours from first dose of antibiotic (cases) or 72 hours from birth (controls). We collected renal NIRS values, blood pressure, heart rate, electrolytes, urine output, BUN, creatinine, and oxygen saturation at 1, 3, 12, 24 and 72 hours after antibiotic administration. Minimum, maximum, median, and mean values were calculated and compared for each variable at the defined time points.
